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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell linesand human embryonic kidney 293 cells [HEK293 cells]) as controls. 1395-bp-promoter fragment of XAF1 gene

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: Hepatitis B virus X protein (HBx), a 17-kd protein encoded by X gene of hepatitis B virus (HBV), hasThe HBV X gene was amplified by polymerase chain reaction (PCR), inserted into the eukaryotic expressionPCI-neo containing HBV X gene (pCI-neo-X) was then transfected into cultured GMC line via liposome.TNF-α levels in supernatants in PCI-neo-X transfection without U0126 group were (189.0±18.1

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: CD79B mutation was significantly associated with lower PFS, TMSB4X mutation and high expressionof TMSB4X protein was associated with lower OS.and six mutated genes (BRD4, EBF1, BTG1, CCND3, STAG2, and TMSB4X<

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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High-Throughput Powder Diffraction Using White X-Ray Beam and a Simulated Energy-Dispersive Array Detector Article

Xiaoping Wang, Weiwei Dong, Peng Zhang, Haoqi Tang, Lanting Zhang, Tieying Yang, Peng Liu, Hong Wang, X.

Engineering 2022, Volume 10, Issue 3,   Pages 81-88 doi: 10.1016/j.eng.2021.05.023

Abstract:

High-throughput powder X-ray diffraction (XRD) with white X-ray beam and an energy-dispersive detectorThe X-ray fluorescence (XRF) signal is collected simultaneously.In comparison with ARXRD, the diffraction signal generated by a white X-ray beam over monochromic light

Keywords： High-throughput experiment     White beam X-ray diffraction     Energy-dispersive array detector     Energy-dispersiveX-ray diffraction     Angle-resolved X-ray diffraction    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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The Generating Lock P<G，X，X'>and Its Central Encrypting System

Shi Kaiquan,Chen Zexiong

Strategic Study of CAE 2000, Volume 2, Issue 2,   Pages 41-46

Abstract:

The conception of the generating lock  P <G ,X, X´> and the centralencrypting system composed of P<G ,X, X´>with data generating technology/em>A={x1, x2, …，xn}, XB ={x1,x2,…xm}complete their secret communication with P < G, X, X´>.

Keywords： the generating lock     the central encrypting system     multi-tooth encrypting-decrypting algorithm     P    X     X    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: We propose that the resistance gene flow in nature is “from the natural environments” andand animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 211-217 doi: 10.15302/J-FASE-2019303

Abstract: functions regarding economic traits, and new materials for livestock breeding have been obtained through geneEvaluation is the most important component of the regulation of gene-edited livestock and is a crucialguarantee of public safety before the marketing of gene-edited animal products.Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production

Keywords： evaluation     gene editing     livestock     performance     safety    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 2,   Pages 143-153 doi: 10.1007/s11705-017-1632-4

Abstract: Shape memory polymers (SMPs) are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applications are highlighted.

Keywords： shape memory polymer     biodegradability     biocompatibility     biomedical application     bile acids    

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Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 141-147 doi: 10.1007/s11684-009-0041-6

Abstract: To explore the possibility of Rab9-related gene therapy for neurodegenerative diseases, we packed LentivirusWestern blotting revealed that the Rab9 gene expression in BALB/c mice brain was up-regulated significantlyLentivirus encoding Rab9 can increase the expression of Rab9 gene effectively, which might offer a novel

Keywords： Rab9     lentivirus     gene therapy     gene transfer    

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A study on quality evaluation for bituminous mixture using X-ray CT

Satoshi TANIGUCHI, Keiichiro OGAWA, Jun OTANI, Itaru NISHIZAKI

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 2,   Pages 89-101 doi: 10.1007/s11709-013-0197-7

Abstract: objective of this paper is to propose a new quality evaluation method for asphalt concrete mixture using X-rayTo achieve this aim, asphalt mixtures should be subjected to the X-ray CT scanning and its characteristicscoarse-graded and porous asphalt mixtures were made; 3) materials and mixtures were subjected to the X-ray

Keywords： asphalt concrete mixture     aggregate     bitumen     bitumen content     quality evaluation     X-ray CT    

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Adsorption of fluoride on clay minerals and their mechanisms using X-ray photoelectron spectroscopy

Junyi DU, Daishe WU, Huayun XIAO, Ping LI

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 2,   Pages 212-226 doi: 10.1007/s11783-010-0255-5

Abstract: reaction times by probing their fluoride superficial layer binding energies and element compositions using X-ray

Keywords： clay mineral     fluoride (F)     adsorption mechanism     X-ray photoelectron spectroscopy (XPS)    

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Purification of ice structuring protein complexes from winter wheat using Triton X-114 phase partitioning

Huaneng XU, Haiying CHEN, Weining HUANG,

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4,   Pages 383-385 doi: 10.1007/s11705-009-0249-7

Abstract: purification of ISP complexes from winter wheat was achieved using an aqueous two-phase system of Triton X-

Keywords： separation technique     thermal hysteresis     cold-acclimated     purification     X-114    

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Title Author Date Type Operation

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

High-Throughput Powder Diffraction Using White X-Ray Beam and a Simulated Energy-Dispersive Array Detector

Xiaoping Wang, Weiwei Dong, Peng Zhang, Haoqi Tang, Lanting Zhang, Tieying Yang, Peng Liu, Hong Wang, X.

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

The Generating Lock P<G，X，X'>and Its Central Encrypting System

Shi Kaiquan,Chen Zexiong

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

Journal Article

Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Journal Article

A study on quality evaluation for bituminous mixture using X-ray CT

Satoshi TANIGUCHI, Keiichiro OGAWA, Jun OTANI, Itaru NISHIZAKI

Journal Article

Adsorption of fluoride on clay minerals and their mechanisms using X-ray photoelectron spectroscopy

Junyi DU, Daishe WU, Huayun XIAO, Ping LI

Journal Article

Purification of ice structuring protein complexes from winter wheat using Triton X-114 phase partitioning

Huaneng XU, Haiying CHEN, Weining HUANG,

Journal Article